Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.943 0.109 0.222
biological_process el 70 0.0 0.941 0.133 0.25
biological_process ka 70 0.001 1.0 0.477 0.494
biological_process rf 70 0.0 0.944 0.11 0.223
cellular_component ct 4 0.001 0.294 0.197 0.119
cellular_component el 4 0.001 1.0 0.75 0.432
cellular_component ka 4 0.001 1.0 0.75 0.432
cellular_component rf 4 0.001 1.0 0.75 0.432
disease ct 24 0.002 0.983 0.262 0.373
disease el 24 0.002 0.982 0.228 0.347
disease ka 24 0.005 1.0 0.395 0.469
disease rf 24 0.002 0.98 0.259 0.371
genetic_interaction ct 63 0.0 1.0 0.423 0.327
genetic_interaction el 63 0.0 1.0 0.451 0.333
genetic_interaction ka 63 0.0 1.0 0.937 0.244
genetic_interaction rf 63 0.0 1.0 0.444 0.337
molecular_function ct 7 0.0 1.0 0.216 0.339
molecular_function el 7 0.0 1.0 0.286 0.452
molecular_function ka 7 0.0 1.0 0.286 0.451
molecular_function rf 7 0.0 1.0 0.286 0.452
pathway ct 30 0.001 0.994 0.074 0.179
pathway el 30 0.001 0.207 0.041 0.052
pathway ka 30 0.001 1.0 0.381 0.471
pathway rf 30 0.001 0.197 0.038 0.048
phenotype ct 23 0.0 0.918 0.186 0.284
phenotype el 23 0.0 1.0 0.227 0.344
phenotype ka 23 0.001 1.0 0.567 0.494
phenotype rf 23 0.0 1.0 0.225 0.339
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.001 1.0 0.347 0.471
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.264 0.024 0.05
integration_mean_by_presence el 73 0.0 0.544 0.025 0.076
integration_mean_by_presence ka 73 0.0 1.0 0.181 0.381
integration_mean_by_presence rf 73 0.0 0.366 0.027 0.063
mean ct 73 0.0 0.275 0.023 0.052
mean el 73 0.0 0.482 0.025 0.073
mean ka 73 0.0 1.0 0.182 0.381
mean rf 73 0.0 0.378 0.032 0.071

CDF plots of non integrated kernels

CDF plots of integrated kernels